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. 2004 Mar;123(3):205–216. doi: 10.1085/jgp.200308993

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Modification of R362C/W434F. (A–D) Effect of MTSEA and MTSES modification in oocytes expressing R362C/W434F. Currents recorded by two-microelectrode voltage clamp. Holding and tail potential, −100 mV; 20-mV steps between −140 and +100 mV. Linear capacity–corrected currents used a 20-mV depolarization from +60 mV. Q-V relationships obtained from uncorrected currents (Aggarwal and MacKinnon, 1996). (E) Fractional effect of modification of R362C/W434F on Q _tot. Dashed lines are predictions for adding one positive charge (1.44) or one negative charge (0.56) to each S4 segment. Cationic adducts increase Q _tot by an amount insignificantly different from the predicted 44%, but significantly different from the control (*, P < 0.01). MTSES modification causes a significant reduction of Q _tot (*), but not down to the predicted level.