Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2004 Mar;123(3):281–293. doi: 10.1085/jgp.200308986

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2004, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 10. — The higher affinity site of IVM reduces hP2X₄ receptor channel desensitization. (A) Number of opening per burst (left) and burst duration (right) induced by 0.3 μM ATP as a function of the critical time between bursts of channel activity in the absence (open circles) or presence of 0.3 μM IVM (full circles). (B) Perforated-patch whole-cell currents in response to 2-s application of 30 μM ATP in the absence (left) and presence (right) of 0.2 μM IVM. The cell was incubated for 30 min with 0.2 μM IVM before exposure to ATP. Holding potential −60 mV. Calibration bars, 150 pA (left) and 500 pA (right). (C) Average (±SEM) desensitization after 2-s exposure to 30 μM ATP in the absence (control) and presence of 0.2 μM IVM (n = 8). The statistical significance between the groups was determinate with unpaired Student's t test, where *** represent P < 0.001.