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. 2004 Mar;123(3):281–293. doi: 10.1085/jgp.200308986

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — IVM has two distinct effects on hP2X₄ receptor channels. (A) Whole-cell current traces in response to ATP (3 μM) applied for 3 s every 2 min (short bars) before and during the application of IVM (3 μM), as indicated above the current traces. Holding potential of −60 mV. (B) Superposition of the current traces in A. (C) Whole-cell current traces in response to ATP (10 μM) applied for 3 s every 3 min (short bars) in the presence of IVM (3 μM) and after the washout IVM, as indicated above the current traces. The first exposure to ATP was after the cell was exposed to IVM (3 μM) for 6 min. IVM was washed out 50 s after the first application of ATP. Holding potential of −50 mV. (D) Superposition of the current traces in C.