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. 2004 Mar;123(3):281–293. doi: 10.1085/jgp.200308986

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — Representative current records from an excised outside-out membrane patch exposed to 3 μM ATP. Downward (inward) currents indicate channel opening. Shown is channel activity under control conditions (control), 6 min after exposing the patch to 3 μM IVM (IVM₁) and 6 min after washing out the IVM (wash₁). The application and washout of IVM were repeated (IVM₂ and wash₂). The dashed lines present the average current of the main conductance state during the first exposure to ATP (control). Holding potential −150 mV. Sampled at 50 kHz and filtered at 1 kHz for display.