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. 2004 Mar;123(3):281–293. doi: 10.1085/jgp.200308986

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Copyright © 2004, The Rockefeller University Press

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Figure 9. — The effects of IVM on hP2X₄ receptor channel gating are complex. (A) Distributions of open (left) and shut (right) interval durations for unitary hP2X₄ receptor channel activity recorded from an on-cell patch in response to 0.3 μM ATP under control conditions. The solid lines are the maximum likelihood fits with sums of exponentials. The open and shut intervals were described by the sum of three and five significant exponential components, respectively (patch c02 in Table I). (B and C) Time constants (B) and areas (C) of the open (left) and shut (right) significant exponential components fitted to the dwell-time distributions of the channels exposed to 0.3 μM ATP alone (open circles), 0.3 μM ATP plus 0.3 μM IVM (empty triangle), or 0.3 μM ATP plus 1.5 μM IVM (full triangle). The values are presented in Table I.