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. 2004 Apr;123(4):417–426. doi: 10.1085/jgp.200308919

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Whole-cell recording in mid/late trophozoite-infected red blood cells (RBCs). (A) Light micrograph of a parasitized erythrocyte recorded by patch-clamp techniques before (left, on-cell mode) and after rupture of the aspirated membrane (right, whole-cell mode). Note the bleaching of the erythrocyte cytosol by dialysis of the hemoglobin upon break-in into the whole-cell mode. The ghost membrane is indicated by arrows. (B) Scheme depicting the membrane organization of a trophozoite-parasitized erythrocyte (RBCM, red blood cell membrane; PPM, parasite plasma membrane; PVM, parasitophorous vacuole membrane; FV, food vacuole with hemozoin). (C–E) Transmission light (top line) and fluorescence images (bottom line) of (C) ring-stage–, (D) early and late trophozoite–, and (E) shizont-infected erythrocytes. Infected cells are indicated by the DNA/RNA-specific Syto16-fluorescence. Whole-cell records were obtained from noninfected and mid/late trophozoite-infected erythrocytes.