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. 2004 Apr;123(4):417–426. doi: 10.1085/jgp.200308919

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Comparison of the mannitol inhibition on the P. falciparum–induced lactate or Cl⁻ current. (A) Original current traces recorded from an infected cell (from −100 to +80 mV) before, and immediately after hyperosmotic addition of mannitol (200 mM) to the Na-l-lactate bath solution and after wash-out (Na-l-lactate pipette solution). (B) Mean I-V relation (±SE; n = 4) of the normalized current fraction which was sensitive to mannitol as recorded in A. The mannitol sensitive current fraction (ΔI = I_control − I_mannitol) of the individual experiments was normalized to the control current at +100 mV voltage. (C) Inhibition of outward conductance by addition of neutral carbohydrates to the bath. Shown is the normalized inhibition of the outward conductance (ΔG = (G_control − G_manntiol)/G_control as calculated between +20 and +80 mV voltage; ±SE, n = 4) with lactate (data from A and B) or with chloride (NMDG-Cl pipette and NaCl bath solution) as principal anion.