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. 2004 Apr;123(4):327–340. doi: 10.1085/jgp.200409031

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Dose-dependent block of mBest2-expressed currents by extracellular SCN⁻. The experiments were performed as in Fig. 8. (A and B) I-V relationships of wild-type– (A) or S79C (B) mBest2-expressing HEK-293 cells with different extracellular solutions in which varying amounts of Cl⁻ (5–140 mM) were replaced with equimolar amounts of [SCN⁻] as indicated. (C and D) The currents in A and B were replotted versus driving force (V_m-E_rev) for each anion mixture. (E) Dose-dependent block by SCN⁻. The relative current at +100 mV in C and D for each anion mixture was plotted as a function of [SCN⁻] for wild-type (filled squares, n = 5) and the S79C mutation (open circles, n = 6).