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. 2005 Feb;125(2):237–246. doi: 10.1085/jgp.200409173

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Effect of high [K⁺]_o and muscle acidification on M-wave area and tetanic force in muscles from 4-wk-old animals. Muscles were incubated in Krebs-Ringer buffer equilibrated with 5% CO₂ in O₂. After determination of control values at 4 mM K⁺, [K⁺]_o was increased to 11 mM, and after 70 min the muscles were acidified by increasing CO₂ to 24%, as indicated in A. Muscle contractions were elicited every 10 min via stimulation of the motor nerve with a 1.5-s train of 30-Hz pulses. (A) Time course of M-wave area (○) and tetanic force (•). Data show means ± SEM from three muscles with 100% force corresponding to 0.32 ± 0.01 N. (B) Representative M-wave traces from a single muscle obtained at the time points indicated by a, b, and c in A.