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. 2005 May;125(5):455–464. doi: 10.1085/jgp.200509269

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Copyright © 2005, The Rockefeller University Press

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Figure 2. — GTP-γ-S induces a light-triggered persistent modulation of voltage-activated current kinetics. (A) Depolarizing voltage-clamp steps delivered at 10-mV increments from a holding potential of −80 mV in the dark, in a photoreceptor subjected to intracellular perfusion with 100 μM GTP-γ-S via the patch electrode. The first family of traces (left) was recorded after several minutes of dialysis in the dark. The cell was then briefly illuminated (500 ms; light monitor trace not drawn to scale) and then dark adapted again for 3 min. The voltage stimulation series was repeated (right), producing outward currents that exhibited a noticeably reduced decay. (B) Pooled values of the plateau:peak ratio measured with a depolarizing step to −10 mV depolarization in the dark, in GTP-γ-S–treated photoreceptors before and after exposure to a brief light stimulation (n = 6). Error bars denote standard deviation.