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. 2005 Apr;125(4):413–426. doi: 10.1085/jgp.200409242

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Copyright © 2005, The Rockefeller University Press

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Figure 9. — Kinetic model for spermine or bis-QA_C10 block of the IRK1 channel. Binding of a blocker (B) to a channel (Ch) produces two sequentially related blocked states (ChB₁ and ChB₂). Top, cartoon representing the three channel states (see also Guo et al., 2003; Guo and Lu, 2003; Lu, 2004). The position of K⁺ ions (maximally totaling five) in the inner pore is arbitrary. The rate constants (k_x) and associated valences (z_x) for each blocker are tabulated below.