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. 2005 Apr;125(4):347–359. doi: 10.1085/jgp.200409221

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Putative transmembrane regions of P2X receptor channels. (A) Schematic representation of the general topology of a P2X receptor channel subunit. (B) Sequence alignment of TM1 (left) and TM2 (right) of P2X₄ receptor channels from different species (top) and of rat P2X₁–P2X₇ (bottom). Bold residues are identical across all known P2X receptor channels (except for a Y to F substitution in Xenopus P2X₇). The major findings of this study are summarized above the sequences. X indicates mutations to tryptophan that result in nonconducting channels. Empty circles and bars indicate positions and regions of large perturbations in EC₅₀ induced by the mutations, respectively.