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. 2007 Dec 12;25(1):72–86. doi: 10.1007/s11095-007-9504-0

Fig. 2.

Fig. 2

A schematic diagram depicting the location of siRNAs in association with viral open reading frames and viral mRNAs within the HBV genome. Downward red arrows indicate the location of RNAi target sites within the four HBV transcripts, the siRNA4 targets to the common HBV polyadenylation signal region. The 3.5 kb transcript is the pregnomic RNA that serves as the template for HBV DNA replication and encodes the viral core and polymerase protein. 2.4 kb and 2.1 kb mRNA encode the viral envelope proteins. 0.7 kb mRNA encodes the viral X protein.