Table 2. Effect of ivermectin and tribendimidine (different doses) against adult S. ratti harbored in rats.
| Treatment | Dose (mg/kg) | No. of rats cured*/investigated | Mean larval burden (SD) | Mean adult worm burden (SD) | Total larval burden reduction (%) | KW | P-value | Total adult worm burden reduction (%) | KW | P-value |
| Control 1a | No treatment | 0/4 | 1012 (640) | 413 (284) | - | - | - | - | - | - |
| Control 2b | No treatment | 0/4 | 2025 (1001) | 750 (387) | - | - | - | - | - | - |
| Tribendimidine | 12.5b | 0/4 | 925 (846) | 125 (96) | 54.3 | 6.83 | 0.041 | 83.3 | 9.46 | 0.008 |
| 25b | 0/4 | 175 (150) | 0 | 91.4 | 100 | |||||
| 50a | 4/4 | 0 | 0 | 100 | 14.61 | 0.002 | 100 | 10.28 | 0.016 | |
| 100a | 4/4 | 0 | 0 | 100 | 100 | |||||
| 200a | 4/4 | 0 | 0 | 100 | 100 | |||||
| Ivermectin | 2.5a | 4/4 | 150 (150) | 0 | 90 | 4.58 | 0.032 | 100 | 4.0 | 0.045 |
*: number of rats without S. ratti.
a
first experiment.
b
second experiment.
KW: Kruskal-Wallis.
SD: standard deviation.