Table 3. Effect of a single 50 mg/kg oral dose of tribendimidine against immature stages of S. ratti harbored in rats.
| Treatment | Treatment day post-exposure (stage) | No. of rats cured*/investigated | Mean larval burden (SD) | Mean adult worm burden (SD) | Total larval burden reduction (%) | Total adult worm burden reduction (%) |
| Control | No treatment | 0/4 | 2375 (1190) | 150 (58) | - | - |
| Tribendimidine | 1 (L3 larvae in lungs or in cranial or nasal cavities)a | 0/4 | 2800 (2546) | 225 (263) | 0 | 0 |
| 2 (some preadolescent stages in intestine)a | 0/4 | 1400 (716) | 50 (58) | 41.1 | 61.5 | |
| 3 (some preadolescent stages in intestine)a | 0/4 | 25 (50) | 50 (58) | 98.9 | 61.5 |
*: number of rats without S. ratti.
a
Harder et al. (2001) [25].
Kruskal-Wallis (KW) testing difference in total larval burden reduction (KW = 9.66, df = 3, P = 0.021) and adult worm burden reduction (KW = 6.29, df = 3, P = 0.098).
SD: standard deviation.