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. 1999 Jul 6;96(14):8064–8069. doi: 10.1073/pnas.96.14.8064

Figure 1.

Figure 1

Map of the 1,000-kb 11p15.5 imprinted domain. The relative location and sizes of genes are drawn approximately to scale, with genes shown to be regulated by genomic imprinting as solid black boxes. Imprinted expression of ORCTL2S, TAPA1(CD81), TH, and INS (gray boxes) has not yet been established, although Tapa1 and Ins have restricted allele-specific expression in the mouse (22). Presented below the map is an enlargement of the KvLQT1 locus showing its exon–intron structure (nomenclature from Lee et al.; ref. 38) as determined by comparison of the mRNA (GenBank accession no. U89364) and genomic sequences (GenBank accession nos. AC001228, AC003675, U90095, AC002403, AC000377, and AC003693), and the position of the intronic, differentially methylated CpG island KvDMR1 and NotI (N) sites. The direction of transcription of the maternally expressed KvLQT1 gene and the paternally expressed antisense transcript (KvLQT1-AS) are indicated. The approximate locations of the Beckwith–Wiedemann syndrome (BWS) and rhabdoid tumor (Rhd) 11p15.5 rearrangement breakpoints are shown. cen, centromere; tel, telomere.