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Expression of soluble CD28 and CD154 correlates with lethality in human sepsis. Levels of soluble CD154 (sCD154; A) and soluble CD28 (sCD28; B) were measured by ELISA in healthy control subjects (n = 11) and septic subjects (n = 35) on Day 1. Levels for both were higher in nonsurvivors (n = 6) compared with survivors (n = 29). Data were analyzed by nonparametric analysis of variance, P < 0.001. Statistically significant group comparisons are bracketed.
