Figure 2.
Experimental measurements (open circles, mean ± SE) of the time courses of impedance parameters R, G, and H after increasing doses of methacholine aerosol in four groups of BALB/c mice. The solid lines show the corresponding predictions of the three parameters obtained using an anatomically based computational model of the mouse lung. The vertical arrows along the bottom indicate the start times of 40-second exposures to methacholine at the indicated concentrations. Deep inflations of the lung to a pressure limit of 25 cm H2O were given before each exposure. Ova = ovalbumin; PLL = poly-l-lysine.