Figure 3.

Computational model prediction of the effect of simultaneous allergic inflammation and treatment with 100 μg intratracheal poly-l-lysine (PLL) on airway responsiveness in BALB/c mice, compared with either treatment separately and with untreated (naive) animals. R, G, and H are the three parameters characterizing the input impedance, Z. The data shown are mean ± SE obtained from a Monte-Carlo simulation in which the model was run 16 times, each time using a different random sampling of the baseline airway diameters for the mouse tabulated by Gomes and Bates (54) after modification so that the simulated Z matched that measured in the BALB/c mouse (14). Ova = ovalbumin.