Figure 1.

Effect of SCF and IL-4 on human intestinal MC proliferation. Enriched MC preparations obtained by positive selection of c-kit-expressing cells were cultured in medium alone or supplemented with IL-4 (10 ng/ml), SCF (25 ng/ml), or both. MC recovery, expressed in percent (start of culture = 100%), is shown (means + SD of 12 experiments performed in duplicate). Analogous results were obtained with unpurified cell preparations containing 2–8% MC (not shown). Statistical analysis by Wilcoxon test; n.s., not significant.