Table 1.

Polymorphisms and disease in the human CXC subfamily.

Ligand	Polymorphism	Location	Symbol	Disease involved	References
CXCL2	Tandem repeat -665(AC)n	Promoter		Severe sepsis	[28]
CXCL8	Microsatellite		D4S2641	Diffuse parabronchiolitis	[64]
	SNP -845 (C/T)	Promoter	rs2227532	SLE nephritis	[16]
	SNP -251 (A/T)	Promoter	rs4073	Asthma	[13]
				RSV infection	[8, 9, 14]
				Smoking behaviour	[7]
				Oral squamous cell carcinoma	[65]
				EAEC diarrhoea	[10]
				Clostridium difficile diarrhoea	[66]
				Helicobacter pylori-induced gastric diseases	[11, 67–70]
				Acute pancreatitis severity	[71]
				Gastric cancer	[12, 72, 73]
				Colorectal cancer	[74]
				Prostate cancer	[75]
				Parkinson's disease	[76]
				Multiple sclerosis	[77]
				Multiple system atrophy	[78]
				AIDS-related Kaposi's sarcoma	[79]
				Acute pyelonephritis	[17]
	SNP +781 (C/T)	Intron 1	rs2227306	Asthma	[13, 15]
	SNP +1633 (C/T)	Intron 3	rs2227543	Asthma	[13]
	SNP +2767 (A/T)	3′UTR	rs1126647	Asthma	[13]
				Nephritis in cutaneous vasculitis	[18]
				Acute pyelonephritis	[17]
	Haplotypes			Behcet's disease	[80]
CXCL10	Haplotypes			Multiple sclerosis	[81]
CXCL11	DIP -599del5	Promoter		Hepatitis C virus (HCV) infection	[29]
CXCL12	SNP +801 (G/A)	3′UTR	rs1801157	HIV-1 infection	[20, 22–24]
				Atherosclerosis in HIV patients	[82]
				Breast and lung cancer	[83–85]
				Acute myeloid leukemia	[86]
				Lymphoma	[87]
				Chronic myeloproliferative disease	[88]
				Liver transplantation	[89]
				Type 1 diabetes	[90]
CXCL16	SNP +599 (C/T)	Exon 4	rs2277680	Coronary artery stenosis	[30]