Table 2.
Single nucleotide polymorphisms in the FCN2 gene (sites ss32469536 and ss7851696) in patients with various l-ficolin serum concentration ranges.
| ≤ 2·0a | > 2·0 ≤ 2·8a | ≤ 2·8a | ≥ 4·5a | |
|---|---|---|---|---|
| ss32469536 (promoter): numbers (%) | ||||
| AA (normal homozygous) | 14 (48·3) | 50 (87·7) | 64 (74·4) | 51 (85·0) |
| AC (heterozygous) | 11 (37·4) | 5 (8·8) | 16 (18·6) | 8 (13·3) |
| CC (variant homozygous) | 4 (13·8) | 2 (3·5) | 6 (7·0) | 1 (1·7) |
| P = 0·037b | P = 0·61b | P = 0·24b | ||
| P = 0·17c | ||||
| AC + CC (variant carriers) | 15 (51·7) | 7 (12·3) | 22 (25·6) | 9 (15·0) |
| P = 0·0006b | P = 0·79b | P = 0·15b | ||
| P = 0·0007c | ||||
| rs7851696 (exon 8): numbers (%) | ||||
| GG (normal homozygous) | 13 (44·8) | 49 (86·0) | 62 (72·1) | 51 (86·4) |
| GT (heterozygous) | 12 (41·4) | 8 (14·0) | 20 (23·3) | 8 (13·6) |
| TT (variant homozygous) | 4 (13·8) | 0 (0·0) | 4 (4·7) | 0 (0·0) |
| P = 0·01b | P = 1·0b | P = 0·15b | ||
| P = 0·011c | ||||
| GT + TT (variant carriers) | 16 (55·2) | 8 (14·0) | 24 (27·9) | 8 (13·6) |
| P = 0·0001b | P = 1·0b | P = 0·044b | ||
| P = 0·0001c | ||||
| pair ss32469536/rs7851696: numbers (%) | ||||
| AAGG (normal homozygous) | 13 (44·8) | 49 (86·0) | 62 (72·1) | 49 (84·5) |
| (heterozygous) | 12 (41·4) | 8 (14·0) | 20 (23·3) | 9 (15·5) |
| CCTT (variant homozygous) | 4 (13·8) | 0 (0·0) | 4 (4·7) | 0 (0·0) |
| P = 0·011b | P = 1·0b | P = 0·15b | ||
| P = 0·011c | ||||
| 16 (55·2) | 8 (14·0) | 24 (27·9) | 9 (15·5) | |
| Variant carriers | P = 0·0003b | P = 1·0b | P = 0·11b | |
| P = 0·0001c |
a
Concentrations given in µg/ml
b
versus ≥ 4·5
c
versus > 2·0 ≤ 2·8.