Table 3.
Single nucleotide polymorphisms in the FCN2 gene (sites ss32469537 and ss32469544) in patients with various l-ficolin serum concentration ranges.
| ≤ 2·0a | > 2·0 ≤ 2·8a | ≤ 2·8a | ≥ 4·5a | |
|---|---|---|---|---|
| ss32469537 (promoter): numbers (%) | ||||
| AA (normal homozygous) | 17 (58·6) | 22 (40·7) | 39 (47·0) | 17 (30·4) |
| AG (heterozygous) | 12 (41·4) | 29 (53·7) | 41 (49·4) | 28 (50·0) |
| GG (variant homozygous) | 0 (0·0) | 3 (5·6) | 3 (3·6) | 11 (19·6) |
| P = 0·013b | P = 0·043b | P = 0·003b | ||
| P = 0·55c | ||||
| AG + GG (variant carriers) | 12 (41·4) | 32 (59·3) | 44 (25·6) | 39 (69·6) |
| P = 0·019b | P = 0·32b | P = 0·055b | ||
| P = 0·17c | ||||
| ss32469544 (exon 8): numbers (%) | ||||
| CC (normal homozygous) | 17 (58·6) | 24 (42·1) | 41 (47·7) | 14 (23·7) |
| CT (heterozygous) | 12 (41·4) | 28 (49·1) | 40 (46·5) | 31 (52·5) |
| TT (variant homozygous) | 0 (0·0) | 5 (8·8) | 5 (5·8) | 14 (23·7) |
| P = 0·004b | P = 0·043b | P = 0·002b | ||
| P = 0·16c | ||||
| CT + TT (variant carriers) | 12 (41·4) | 33 (57·9) | 45 (52·3) | 45 (76·3) |
| P = 0·002b | P = 0·048b | P = 0·0004b | ||
| P = 0·17c | ||||
| pair ss32469537/ss32469544: numbers (%) | ||||
| AACC (normal homozygous) | 17 (58·6) | 20 (37·0) | 37 (44·6) | 14 (25·0) |
| (heterozygous) | 12 (41·4) | 31 (57·4) | 43 (51·8) | 31 (55·4) |
| GGTT (variant homozygous) | 0 (0·0) | 3 (5·6) | 3 (3·6) | 11 (19·6) |
| P = 0·013b | P = 0·043b | P = 0·003b | ||
| P = 0·55c | ||||
| 12 (41·4) | 34 (63·0) | 46 (55·4) | 42 (75·0) | |
| Variant carriers | P = 0·004b | P = 0·22b | P = 0·021b | |
| P = 0·068c |
a
Concentrations given in µg/ml
b
versus ≥ 4·5
c
versus > 2·0 ≤ 2·8.