Figure 2.

Endometriosis-like lesions in Lepr^dbm (A–D) and Lepr^db hosts (E–H). After uterine tissue transfer, each host type received uterine tissue from the female siblings of the opposite genotype of the same litter. Seven days after transfer, Lepr^dbm animals (received Lepr^db tissue) displayed multiple vascular lesions (A), compared with the purulent nonvascular sites in Lepr^db hosts (received Lepr^dbm tissue) (E). In long-term studies (14 d after transfer), lesions of the Lepr^dbm hosts appeared significantly more vascularized grossly and invasive at multiple sites (B and C) in contrast to Lepr^db hosts, which did not display significant vascularization or mottling, and demonstrated marked purulence and necrosis (F and G). Microscopic comparison (hematoxylin and eosin) revealed glandular architecture and organization in Lepr^dbm hosts (D) similar to that seen in the WT syngeneic transfer model. Lepr^db showed diffuse necrosis and glandular and stromal disruption (H). Microscopic images (hematoxylin and eosin), ×60. Scale bars, 100 μm.