Fig. 3.

WY14,643 feeding improves renal histology in anti-glomerular basement membrane disease (AGBMD). C57BL/6 mice were fed 0·05% WY14,643 or control food and then immunized to induce AGBMD. Six months after induction of disease kidney sections were stained with haematoxylin and eosin. (a and b) Control-treated animals versus (c and d) WY14,643-treated animals (a, c, 100×; b, d, 400×). (e) Kidney sections were graded qualitatively by a blinded observer using 0–4 criteria (Table 1). There was a significant difference in control versus WY14,643-fed mice. P < 0·01 by the Mann–Whitney U-test, N = 26.