Table 2.
Risks of possible early-onset sepsis (EOS) and EOS compared to no EOS according to mannose-binding lectin (MBL) plasma levels, MBL2 genotype, gestational age and other selected clinical characteristics.
| Possible EOS | EOS | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | n | OR | 95% CI | P-value | n | OR | 95% CI | P-value |
| Pregnancy-related disease | ||||||||
| No | 37 | Ref | 10 | Ref | ||||
| Yes | 8 | 0·3 | 0·1–0·8 | 0·02 | 1 | 0·1 | 0·0–1·1 | n.s. |
| Fetal distress | ||||||||
| No | 25 | Ref | 4 | Ref | ||||
| Yes | 20 | 0·5 | 0·2–1·4 | n.s. | 7 | 1·2 | 0·3–4·9 | n.s. |
| Gestational age (1 week↑) | 45 | 1·0 | 0·9–1·1 | n.s. | 11 | 1·0 | 0·8–1·2 | n.s. |
| Mode of delivery | ||||||||
| Vaginal | 22 | Ref | 7 | Ref | ||||
| Caesarean section | 23 | 0·2 | 0·1–0·7 | < 0·01 | 4 | 0·1 | 0·0–0·6 | < 0·01 |
| MBL plasma level (1 µg/ml↑) | 44 | 0·7 | 0·4–1·1 | n.s. | 11 | 0·2 | 0·1–0·7 | 0·01 |
| MBL plasma level | ||||||||
| Normal (> 0·7 µg/ml) | 27 | Ref | 3 | Ref | ||||
| Low (≤ 0·7 µg/ml) | 18 | 1·7 | 0·6–4·5 | n.s. | 8 | 6·8 | 1·5–31·6 | 0·01 |
| MBL plasma level | ||||||||
| Plasma level > 0·2 µg/ml | 38 | Ref | 5 | Ref | ||||
| Plasma level (≤ 0·2 µg/ml | 7 | 2·8 | 0·5–14·3 | n.s. | 6 | 18·0 | 2·8–115·6 | < 0·01 |
| MBL2 genotype | ||||||||
| Wild-type (YA/YA, YA/XA, XA/XA) | 25 | Ref | 3 | Ref | ||||
| Variant (YA/O, XA/O, O/O) | 13 | 3·3 | 0·8–13·2 | n.s. | 7 | 14·8 | 2·4–91·2 | < 0·01 |
OR, odds ratio; CI, confidence interval; Ref, reference; n.s., not significant. Multinominal logistic regression was used.