Fig. 1.

A schematic diagram of (a) CD55 and (b) CD46 mRNA with selected phosphorothioate oligonucleotides (S-ODNs) hybridizing to different target regions. Numbers of S-ODNs in parentheses correspond to the position of the first nucleotide of the respective target sequence. S-ODNs indicated by arrows reveal most potent anti-sense activity (see Fig. 1). 5′-UTR, 5′-untranslated region; signal, signal peptide; SCR, short consensus repeat; STP, serine–threonine–proline-rich region; CTD, C-terminal domain; UK, area of unknown significance; TM, transmembrane region; Cyt, cytoplasmic domain; 3′-UTR, 3′-untranslated region.