Table 1.
Genome-wide scan for loci linked with severe nephritis in (NZB × NZW)F1 × NZB backcross mice*
| Locus | Position
|
Linkage
|
|||
|---|---|---|---|---|---|
| Chromosome no. | Distance from centromere, in centimorgans (cM) | χ2 | P value | Odds ratio† | |
| MHC (Tnf) | 17 | 19 | 69 | 8 × 10−17 | 31 |
| D7Nds5‡ | 7 | 23 | 4.4 | 0.036 | 2.1 |
| D7Mit148‡ | 7 | 46 | 4.7 | 0.030 | 2.1 |
| D16Mit6‡ | 16 | 60 | 4.9 | 0.027 | 2.2 |
| D19Mit11‡ | 19 | 41 | 4.6 | 0.032 | 2.1 |
| D1Nds1§ | 1 | 67 | 0.3 | >0.5 | ∼1.0 |
| D1Mit106§ | 1 | 85 | 0.01 | >0.5 | ∼1.0 |
| D4Mit71§ | 4 | 62 | 0.00 | >0.5 | ∼1.0 |
| D4Mit179§ | 4 | 71 | 0.03 | >0.5 | 1.1 |
Data were obtained from at least 145 backcross mice for each marker shown.
Odds ratio represents the increased risk for development of nephritis and is calculated as [(No. heterozygous diseased mice) × (No. NZB homozygous healthy mice)] ÷ [(No. NZB homozygous diseased mice) × (No. heterozygous healthy mice)].
Although these loci do not meet accepted thresholds (P < 0.0034) for suggestive linkage, their trends for linkage with nephritis are shown because they show suggestive linkage with various serological traits.
These loci have been reported to contribute strongly to nephritis in other analyses but failed to show even trends for linkage with nephritis or with serological traits in the current analysis.