TABLE 1.
Identification of known Notch pathway genetic interactors
| Gene | N | mam | Dl/Ser | C96-MamN | C96-GAL4 |
|---|---|---|---|---|---|
| Beadex (Bx) | NA | + | + | E/S | +/NE |
| Delta (Dl) | + | + | + | E/E/E/S | NE/+/NE/+ |
| echinoid (ed) | + | NA | + | S | NE |
| extra macrochaete (emc) | + | NA | + | S | NE |
| escargot(esg) | +* | + | NA | E | + |
| eyegone (eyg) | + | NA | NA | E | + |
| fringe (fng) | + | NA | + | E/E | +/+ |
| frizzled (fz) | + | NA | + | S | NE |
| hephaestus (heph) | + | NA | + | S | NE |
| inscuteable (insc) | + | NA | NA | S/S | NE/NE |
| kekkon-1 (kek1) | NA | + | NA | E | + |
| kismet (kis) | + | NA | NA | E | NE |
| kuzbanian (kuz) | + | NA | + | S | NE |
| mastermind (mam) | + | + | + | E/S | NE/NE |
| net | NA | NA | + | E | NE |
| nemo (nmo) | + | NA | + | S | NE |
| Neurotactin (Nrt) | + | NA | NA | E | NE |
| numb | + | NA | NA | E/E | NE/NE |
| osa | + | NA | NA | E | NE |
| pointed (pnt) | + | NA | NA | E/E | NE/NE |
| polychaetoid (pyd) | + | NA | + | Other | NE |
| puckered (puc) | + | NA | NA | E/S/S | +/NE/NE |
| Ras85D | + | + | NA | E | NE |
| rugose (rg) | NA | NA | + | S | NE |
| scabrous (sca) | + | NA | + | E | NE |
| shaggy (sgg) | + | + | NA | E | NE |
| sprouty (sty) | +* | NA | +* | S | NE |
| split ends (spen) | + | NA | NA | S | NE |
| string (stg) | + | NA | NA | E | NE |
| Ultrabithorax (Ubx) | + | NA | NA | S | NE |
| wingless (wg) | + | + | + | Other | + |
A list of 31 genes previously associated with Notch-signaling activity (Grumbling and Strelets 2006) identified as C96-MamN modifiers. Of these 31 genes, 24 are known to interact genetically with N, and, of these 24, 15 were defined as NIs and are underlined. Known interactors of other Notch pathway members defined as novel NIs are double underlined. Interactions of genes with Notch (N), mastermind (mam), Delta or Serrate (Dl/Ser), C96-MamN, or C96-GAL4 are listed. NA, not available; NE, no effect; +, interaction; +*, interaction from G. D. Hurlbut, M. W. Kankel and S. Artavanis-Tsakonas, unpublished results; E, enhances; S, suppresses. Multiple entries for a given gene under the “C96-MamN” and “C96-GAL4” columns indicate multiply recovered alleles and different entries refer to the type of interaction for each allele.