Table 2.
CB2 receptors and microglial function (in vivo data)
| Reference | Insult/disease model | Ligand(s) | Receptor mediation | Molecular effects of cannabinoid agonists | Symptomatic effects of cannabinoid agonists | Animal species |
|---|---|---|---|---|---|---|
| Arevalo-Martin et al. (2003) | Theiler's virus | WIN55212-2 ACEA JWH-015 |
CB1 mediated CB2 mediated |
↓ Microglial activation ↓ MHC-II expression ↓ CD4+ infiltration |
Motor recovery Remyelination |
Mouse |
| Zhang et al. (2003) | Chronic constriction injury Freund's complete adjuvant injection Spinal nerve ligation |
None | ↑ CB2 mRNA | Not studied | Not studied | Rat |
| Maresz et al. (2005) | Experimental autoimmune enchepalomyelitis | None | Not studied | ↑ CB2 | Not studied | Mouse |
| Beltramo et al. (2006) | Spinal cord ligation | AM1241 L768242 SR144528 |
CB2 mediated | ↑ CB2 | ↓ Hyperalgesia | Mouse |
| Mukhopadhyay et al. (2006) | LPS | None | Not studied | ↑ CB2 | Not studied | Rat |
| Ashton et al. (2007) | Middle cerebral artery occlusion Hypoxia–ischemia |
None | Not studied | ↑ CB2 | Not studied | Rat |