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Concentration–response effects of JWH015 (a) and JWH133 (b) on synovial blood flow. The selective CB2 receptor antagonist AM630 (10−8 mol) was unable to block the vasodilator effect of JWH015, but significantly attenuated the hyperaemic response of JWH133 (***P<0.001, **P<0.01 vs control; two-way ANOVA followed by Bonferroni post hoc test; n=11–38). Data are presented as mean percent change in perfusion±s.e.m.
