Table 1.

MAP taken before (control) and at 1.5 min following topical application of the CB2 receptor agonists JWH015 and JWH133, and the CB2 receptor antagonist AM630

Drugs	MAP (mm Hg)	n values
JWH015 (mol)
Control	77±5	10
10−14	75±4	10
Control	75±5	10
10−13	73±4	10
Control	74±4	10
10−12	73±3	10
Control	71±3	10
10−11	69±2	10
JWH133 (mol)
Control	89±3	41
10−14	87±4	38
Control	90±4	38
5 × 10−14	88±5	28
Control	88±5	28
10−13	82±5	23
Control	82±5	24
5 × 10−13	75±6	11
Control	85±5	28
10−12	89±6	19
AM630 (mol)
Control	94±5	17
10−8	93±6	17
SB366971 (μg kg−1)
Control	94±9	8
500	93±9	10

The effect of the TRPV1 antagonist SB366791 on MAP is also shown (values are expressed as means±s.e.m.).

Abbreviation: MAP, mean arterial pressure.