Figure 2.

The phenotype of heterophile antibodies clusters in families with type 1 diabetes. Serum samples and DNAs were obtained from a previously characterized cohort of multiplex and simplex families harboring diabetic probands and individuals with other autoimmune disorders (5, 15). Heterophile antibody levels were determined as described (11). The pedigrees for the five families that had two or more subjects with heterophile antibodies are pictured. Only one individual in these families had both type 1 diabetes and heterophile antibodies. The HLA-DQB1 alleles for each subject are pictured. Individual alleles for the DQB1*05 family were not further subtyped and are represented as 500. In addition, the diabetes-protective DQB1*0602 alleles are underlined (602).