Table 5.
Indirect Comparisons of Pharmacological Treatment Categories
| Comparison | Difference in SOL (min)/Risk Difference | 95% Confidence Interval (min) | Difference Favors | Significant Difference (Yes or No) |
|---|---|---|---|---|
| Sleep onset latency as measured by polysomnography | ||||
| BDZ versus non-BDZ | 2.8 | −4.9, 10.5 | non-BDZ | No |
| BDZ versus ADP | −3.1 | −10.6, 4.5 | BDZ | No |
| non-BDZ versus ADP | −5.9 | −11.3, −0.4 | non-BDZ | Yes |
| Sleep onset latency as measured by sleep diary | ||||
| BDZ versus non-BDZ | −2.6 | −7.8, 2.7 | BDZ | No |
| BDZ versus ADP | −7.4 | −18.3, 3.6 | BDZ | No |
| non-BDZ versus ADP | −4.8 | −15.3, 5.7 | non-BDZ | No |
| Adverse events | ||||
| BDZ versus non-BDZ | 0.08 | 0.02, 0.14 | non-BDZ | Yes |
| BDZ versus ADP | 0.06 | −0.04, 0.16 | ADP | No |
| non-BDZ versus ADP | −0.02 | −0.12, 0.08 | non-BDZ | No |
ADP Antidepressants, BDZ benzodiazepines, min minutes, non-BDZ non-benzodiazepines, SOL sleep onset latency