Table 1.
Parameter | WKY | ACTH | SHR |
Systolic BP (mmHg) | 123 ± 5 (5) | 146 ± 3* (10) | 187 ± 4* (9) |
Circumference (μm) | 745 ± 36 (4) | 628 ± 51 (7) | 610 ± 22 (6) |
Mean SMC layers | 7.2 ± 0.1 (4) | 6.7 ± 0.4 (7) | 8.7 ± 0.4* (5) |
Area of EC (μm2) | 392 ± 9 (5) | 438 ± 13* (6) | 279 ± 4* (3) |
MEGJs/EC | 0.1 ± 0.08 (4) | 0.06 ± 0.04 (4) | 0.03 ± 0.03 (3) |
Mean ± SEM; number of animals in parentheses. *p < 0.05 compared to WKY. Myoendothelial gap junctions (MEGJs) are expressed per endothelial cell (EC). Measurement of EC area from 150 cells (WKY), 76 cells (ACTH) and 45 cells (SHR). SMC = smooth muscle cell. Data for WKY from reference [49].