FIGURE 1. Schematic diagram of TSP constructs.

The N-terminal heparin-binding module (N), oligomerization domain (O), procollagen module (C), properdin modules (P), EGF-like modules (E), Ca²⁺-binding repeats (Ca), and C-terminal sequence (G) are indicated in the diagram. The TSP-4 monomer lacks the procollagen and properdin modules and contains a fourth EGF-like module. An arrow marks the location of Ala³⁸⁷ in TSP-4 that is changed to Pro³⁸⁷ in the polymorphism (14). The constructs described in the paper are named according to the modules present and from which TSP form the modules are derived.