Table 3.
Hematopoietic reconstitution by NA cells from LTBMC
| Cell source | Weeks after transplant
|
|||
|---|---|---|---|---|
| 3 | 6 | 12 | 24 | |
| Two-month LTBMC† | ||||
| Fresh marrow | 86 ± 8.4 (3/3) | 61.7 ± 14.0 (3/3) | 61.6 ± 15.0 (3/3) | 67.2 ± 4.7 (3/3) |
| Control LTBMC | 22.7 ± 7.7 (4/4) | 7.3 ± 2.9 (3/3) | 1.7 ± 1.5 (4/4) | 0.58 ± 0.57 (2/4) |
| TPO-LTBMC | 94.0 ± 4.8 (3/3) | 70.4 ± 15.6 (3/3) | 62.1 ± 20.5 (3/3) | 53.7 ± 32.5 (3/3) |
| Three-month TPO-LTBMC‡ | ||||
| 25,000 | 4.7 ± 5.4 (3/4) | 0.8 ± 1.6 (1/4) | 0.8 ± 1.6 (1/4) | 0.5 ± 1.0 (1/4) |
| 50,000 | 11.5 ± 8.6 (2/2) | 12.3 ± 7.1 (2/2) | 9.0* | 43.6* |
| 100,000 | 39.0 ± 11.0 (3/3) | 34.4 ± 15.0 (3/3) | 26.2 ± 4.1 (3/3) | 17.4 ± 5.4 (3/3) |
| 200,000 | 38.9 ± 9.1 (3/3) | 29.2 ± 14.4 (3/3) | 41.4 ± 36.3 (3/3) | 36.7 ± 41.7 (3/3) |
| Four-month TPO-LTBMC‡ | ||||
| 100,000 | 14.9 ± 3.3 (4/4) | 3.4 ± 2.4 (4/4) | 1.8 ± 2.0 (4/4) | 0.7 ± 1.2 (1/4) |
| 500,000 | 30.0 ± 17.5 (5/5) | 10.3 ± 1.9 (5/5) | 5.6 ± 1.4 (5/5) | 3.4 ± 1.4 (5/5) |
Numbers indicate the percent (±1 SD) CD45.1+ peripheral blood leukocytes. Numbers in parentheses indicate the number of positive animals (>0.5% CD45.1+)/number transplanted.
*
Only one animal analyzed.
†
Data are pooled from two experiments, with either 5.5 × 105 or 1.3 × 106 cells transplanted per animal.
‡
Number of NA cells transplanted per animal.