Table 2.
Nominally significant associations between prolactin (PRL) and prolactin receptor (PRLR) tagSNPs and plasma PRL levels
| SNP | SNP Name | N (%) | Genotype | LS meansa (95% CI) | pb | |
| PRL | ||||||
| "BLOCK" 2 | ||||||
| SNP 33 | rs1341238 | 167 (64.98) | GG | 7.15 | (6.35 – 8.06) | 0.025 |
| 65 (25.29) | AG | 9.23 | (7.68 – 11.09) | |||
| 25 (9.73) | AA | 9.02 | (6.69 – 12.16) | |||
| SNP 34 | rs9466314 | 248 (96.50) | AA | 7.67 | (6.94 – 8.49) | 0.039 |
| 8 (3.11) | AT | 10.48 | (6.25 – 17.58) | |||
| 1 (0.39) | TT | 31.75 | (7.69 – 131.02) | |||
| SNP 39 | rs3756824 | 246 (81.19) | CC | 7.56 | (6.86 – 8.34) | 0.035 |
| 56 (18.48) | CG | 9.73 | (8.00 – 11.82) | |||
| 1 (0.33) | GG | 6.15 | (1.55 – 24.49) | |||
| SNP 44 | rs2244502 | 145 (47.85) | AA | 6.96 | (6.15 – 7.88) | 0.002 |
| 126 (41.58) | AT | 8.64 | (7.60 – 9.82) | |||
| 32 (10.56) | TT | 10.30 | (7.91 – 13.41) | |||
| BLOCK 3 | ||||||
| SNP 54 | rs849886 | 83 (25.54) | CC | 9.33 | (7.83 – 11.13) | 0.048 |
| 157 (48.31) | CT | 8.22 | (7.31 – 9.24) | |||
| 85 (26.15) | TT | 7.27 | (6.15 – 8.59) | |||
| BLOCK 4 | ||||||
| SNP 62 | rs849870 | 191 (64.09) | CC | 8.72 | (7.81 – 9.72) | 0.013 |
| 96 (32.21) | CT | 7.28 | (6.30 – 8.41) | |||
| 11 (3.69) | TT | 5.66 | (3.69 – 8.70) | |||
| SNP 65 | rs849872 | 142 (47.65) | TT | 8.96 | (7.92 – 10.14) | 0.018 |
| 123 (41.28) | CT | 7.47 | (6.59 – 8.48) | |||
| 33 (11.07) | CC | 6.93 | (5.42 – 8.85) | |||
| PRLR | ||||||
| BLOCK 4 | ||||||
| SNP 73 | rs10941235 | 135 (49.45) | CC | 8.97 | (7.78 – 10.33) | 0.042 |
| 107 (39.19) | CT | 7.09 | (6.13 – 8.20) | |||
| SNP 148 | rs37364 | 136 (49.1) | TT | 7.34 | (6.44 – 8.35) | 0.037 |
| 106 (38.27) | GT | 8.49 | (7.32 – 9.86) | |||
| 35 (12.64) | GG | 9.72 | (7.50 – 12.6) | |||
AA, African Americans; NH, Native Hawaiians; JA, Japanese Americans; LA, Latinas, WH, Whites.
a Least square means of prolactin levels and 95% confidence interval; LS means adjusted for age, ethnicity, and assay batch.
b P-value for test of trend.