Table 1.
Change in concentrations of laboratory data (mean ± SD)*
Sham | BDL | BDL + vehicle | BDL + fenofibrate | |
Bilirubin (mg/dl) | 0.68 ± 0.17 | 9.05 ± 2.24a | 8.98 ± 2.78a | 6.02 ± 1.56a,b,c |
ALT (IU/L) | 45.7 ± 9.7 | 115.7 ± 16.5a | 117.4 ± 20.2a | 82.7 ± 12.0a,b,c |
AST (IU/l) | 78.1 ± 9.6 | 142.8 ± 17.8a | 147.7 ± 24.0a | 99.4 ± 13.6a,b,c |
GGT (IU/l) | 7.7 ± 2.7 | 37.8 ± 8.0a | 34.4 ± 13.1a | 26.4 ± 6.2a,b,c |
ALP (IU/L) | 95.9 ± 19.4 | 408.2 ± 42.4a | 416.0 ± 62.6a | 381.6 ± 36.9a,b |
TBA (μmol/ml) | 3.2 ± 1.2 | 34.3 ± 3.8a | 35.7 ± 2.9a | 26.7 ± 4.1a,b,c |
TNF-α (pg/mL) | 6.2 ± 2.57 | 45.7 ± 4.61a | 43.8 ± 5.86a | 32.7 ± 5.6a,b,c |
IL-1β (pg/mL) | 7.3 ± 3.9 | 130.3 ± 16.6a | 128.3 ± 23.9a | 83.2. ± 11.3a,b,c |
Tissue MDA levels (nmol/mg protein) | 0.5 ± 0.2 | 4.9 ± 1.2a | 4.8 ± 0.9a | 2.1 ± 0.4a,b,c |
*Comparisons between groups were done by using Kruskal-Wallis test. Paired comparisons are done by using Mann-Whitney U test.
aP < 0.01 versus sham group (Mann-Whitney U after Kruskal-Wallis test)
bP < 0.01 as compared to BDL groups (Mann-Whitney U after Kruskal-Wallis test)
cP < 0.01 as compared to BDL + vehicle groups (Mann-Whitney U after Kruskal-Wallis test)