Table 2.
Change in histopathologic scores (mean ± SD)*
Sham | BDL | BDL + vehicle | BDL + fenofibrate | |
Portal inflammation | 0 | 3.2 ± 0.2a | 3.1 ± 0.7a | 2.0 ± 0.5a,b,c |
Interface hepatitis | 0 | 1.8 ± 0.7a | 1.7 ± 0.9a | 1.3 ± 0.6a,b,c |
Confluent necrosis | 0 | 2.2 ± 0.a | 2.1 ± 0.9a | 1.1 ± 0.2a,b,c |
Lobar necrosis | 0 | 3.0 ± 0.9a | 2.9 ± 0.7a | 2.1 ± 0.8a,b,c |
Bile duct number/5 portal field | 3.5 ± 1.3 | 18.9 ± 8.0a | 17.5 ± 7.1a | 23.2 ± 11.1a,b,c |
*Comparisons between groups were done by using Kruskal-Wallis test. Paired comparisons are done by using Mann-Whitney U test.
aP < 0.01 versus sham group (Mann-Whitney U)
bP < 0.01 as compared to BDL group (Mann-Whitney U)
cP < 0.01 as compared to BDL + vehicle group (Mann-Whitney U)