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. 1997 Feb 1;109(2):169–180. doi: 10.1085/jgp.109.2.169

Figure 7.

Figure 7

Nifedipine block in presence of either N- or C-type inactivation. (A) Internal TEA and N-type inactivation compete. The ShD currents obtained with and without internal TEA (2 mM) are shown at the top and the scaled currents are shown below. The scaled currents show a cross-over. (B) Nifedipine block of the macroscopic currents through ShD channels. (C) Macroscopic currents through the ShBΔ6-46 T449K channels with C-type inactivation (control and 100 μM nifedipine). Scaled currents (lower traces) show that the current in the presence of nifedipine inactivates faster. (D) Time constants of ShBΔ6-46 T449K current decline in control and in the presence of 100 μM nifedipine in internal solution. The current traces were fitted with a sum of two exponentials. Each point represents mean ± standard deviation of 12 experiments (Control) or 8 experiments (Nifedipine). (E) Nifedipine block (50 μM) of the ShBΔ6-46 T449V currents without N- or C-type inactivation recorded with different external K+ concentrations. The currents were elicited by depolarizing pulses to +50 mV.