Figure 2.

Structural changes of CCO-generated arterial tree models due to a limit to asymmetry. All four trees were generated with identical constraints, and the optimization target was minimum intravasal volume. Comparing the trees in panels A (upper left), B (upper right), C (lower left), and D (lower right) shows how an increasing restriction on local bifurcation asymmetry changes the global topological and geometrical structure. For a discussion of specific aspects see methods.