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. 2007 Dec 17;2007:62641. doi: 10.1155/2007/62641

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Copyright © 2007 Weiming Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of PPAR-γ agonists on TGF-β1-induced α-SMA, FN, Col III mRNA expression. Cells were cultured as described above and pretreated by 10 uM 15d-PGJ2, troglitazone, and ciglitazone for 2 hours and then added 5 ng/mL TGF-β1. Set a blank control group and 5 ng/mL TGF-β1 stimulating group, cultured for 24 hours and then harvested the cells. Both control and experimental groups repeated for 3 times. (1) control, (2) 5 ng/mL TGF-β1 group, (3) 15d-PGJ2 + 5 ng/mL TGF-β1 group, (4) troglitazone + 5 ng/mL TGF-β1 group, (5) ciglitazone + 5 ng/mL TGF-β1 group, *P < .05 versus control, #P < .05 versus 5 ng/mL TGF-β1 group, $△$ P < .05 versus 15d-PGJ2 group.