Figure 5.

Inhibitory effect of the G71–1 and mfVIIasm immunoconjugates on the growth of a TF2 xenograft. For each curve five SCID mice were injected s.c. with 5 × 10⁵ TF2 cells. When the xenografts had grown to a palpable size, the mice received tail vein injections on days 0, 7, and 14 of the adenoviruses indicated. The amount of adenovirus injected was 4 × 10¹¹ for the control, 2 × 10¹¹ for the adenovirus encoding the G71–1 immunoconjugate, and 4 × 10¹¹ for the adenovirus encoding the mfVIIasm immunoconjugate. The estimated tumor volumes are the averages for the five mice in each group.