Figure 7.

Inhibitory effect of the G71–1 and mfVIIasm immunoconjugates on the growth of a larger TF2 xenograft. Each mouse was injected s.c. with 5 × 10⁵ TF2 cells, and the xenografts were allowed to grow to an estimated tumor volume of 50 mm³ on the skin surface (day 1). A mixture of 2 × 10¹¹ adenoviruses encoding the G71–1 immunoconjugate and 7 × 10¹¹ adenoviruses encoding the mfVIIasm immunoconjugate was injected into the tail vein of five mice on days 1, 6, 12, and 19. As a control five mice were injected with 4 × 10¹¹ adenoviruses that did not encode an immunoconjugate. The estimated tumor volumes are the averages for the five mice in each group. One of the mice injected with the adenoviruses encoding the immunoconjugates was found dead on day 17; the estimated tumor volumes on subsequent days are the averages for the remaining four mice.