Figure 8.

Inhibitory effect of the mfVIIasm immunoconjugate on the growth of an LXSN xenograft. The mice were injected s.c. with 5 × 10⁵ LXSN cells, and when the xenograft had grown to a palpable size (day 0) five mice were injected with 9 × 10¹¹ adenoviruses encoding the mfVIIasm immunoconjugate, and five mice were injected with 4 × 10¹¹ control adenoviruses. Additional injections were done on days 7, 13, 21, and 24, and on day 25 the mice were dissected for morphological and histochemical examination. The estimated tumor volumes are the averages for the five mice in each group.