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. 1999 Jul 6;96(14):8212–8216. doi: 10.1073/pnas.96.14.8212

Figure 2.

Figure 2

Protection of rat cerebrocortical neurons from gp120-induced apoptosis by the β-chemokines RANTES and MIP-1β. (A) Neuroprotection by recombinant rat RANTES (20 nM). (B) Neuroprotection by recombinant human MIP-1β (20 nM). Rat cerebrocortical cultures were incubated for 24 hr with or without 200 pM recombinant gp120 and in the presence or absence of each chemokine. After fixation and permeabilization, neurons were identified by immunostaining for MAP-2 or NeuN, and apoptotic cells were assessed by propidium iodide staining. ∗, P < 0.01 compared with value for gp120.