Figure 4.

Three-dimensional structure of human tau exon 10 splicing regulatory element. Two identical structures are shown, with the phosphate at the exon-intron junction identified in blue. Known FTDP-17 mutations in the stem-loop structure are highlighted in yellow on the right. They include the intronic mutations at positions +3, +13, +14, and +16, as well as the S305N mutation at position −1.