Figure 4.

ATLa₂ does not inhibit PMN recruitment to a site of inflammation by regulating vasodilatation. Mouse arterial pressure was monitored with a pressure transducer via the cannulated carotid artery. Tail vein injection of vehicle (100 μl; 0.9% saline) showed no changes in arterial pressure, whereas 10 μg Iloprost elicited a maximum mean decrease of ≈28 mmHg ≈50 s postinjection, with pressure returning to baseline after ≈500 s. ATLa₂ (10 μg) was injected into three mice with no change in mean arterial pressure. Values represent mean ± SEM (n = 3). See supplemental material on the PNAS web site (www.pnas.org) for additional results.