Figure 20.

Effects of Treatment on Serum and Prostatic Androgen Levels. Both testosterone and dihydrotestosterone levels increased in serum after 6 months of treatment with testosterone replacement therapy (P < .001 by signed rank test). However, despite an increase in serum levels for testosterone to the mid-normal range, prostate tissue levels of the androgens did not change significantly. Boxes contain 50% of data with the inside horizontal line representing the median value; whiskers contain 100% of data, except for statistical outliers shown as individual data points. (Marks et al. JAMA Nov 15, 2006 p2356)